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HEALTH GUIDE · COMMERCIAL DAIRY HERDS

Mastitis Prevention & Treatment for Commercial Dairy Herds

The most costly disease in dairy farming — causing $250–$600 per cow per year. This guide covers the complete five-point prevention and treatment protocol for commercial dairy herds.

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Clinical Protocol & SCC Benchmarks
Citation: Herd Manager Veterinary Protocols · Dairy Pathology 2026

Mastitis Prevention & Somatic Cell Count (SCC): Mastitis is the bacterial inflammation of the mammary gland and the single most expensive disease in dairy farming, inflicting heavy annual losses per cow through lost yield, discarded milk and early culling. Control hinges on keeping Somatic Cell Count (SCC) below 200,000 cells/mL through pre- and post-milking teat dipping, Dry Cow Therapy (DCT), and complete case records — such as the mastitis status you log with each milk record in Herd Manager.

Health Category Somatic Cell Count (SCC) Estimated Milk Loss Action Protocol
Healthy / Normal < 200,000 cells/mL None to minimal Routine pre- and post-dip; monthly CMT screen
Warning (subclinical) 200,000 – 400,000 cells/mL 2% – 7% unnoticed loss CMT to find the quarter; review hygiene and liner vacuum
Action (subclinical) 400,000 – 1,000,000 cells/mL 7% – 16% production drop Vet-guided treatment or culture; review dry-cow therapy
Chronic / Cull risk > 1,000,000 cells/mL >16% loss + culling risk Vet-directed treatment; withhold milk for the full label withdrawal; consider culling

What Is Mastitis?

Mastitis is inflammation of the udder caused by bacterial infection. It is the number one economic disease in dairy farming worldwide.

$250–$600Cost/cow/year
<200,000Target SCC cells/mL
10–25%Milk loss per quarter
3×Culling risk (chronic)
Type Signs SCC Level Treatment
Acute Clinical Hot, swollen quarter; flakes/clots in milk; cow off-feed, fever >1,000,000 Immediate IMM antibiotic + NSAID, systemic if fever >40°C
Subacute Clinical Abnormal milk; mild swelling; cow eating normally 500,000–1,000,000 IMM antibiotic course (3–5 infusions)
Chronic Clinical Recurrent flares; fibrosis; reduced quarter yield Variable — often high Treat or cull — 3+ cases/lactation = cull
Subclinical No visible signs; elevated SCC only 200,000–1,000,000 Dry-cow therapy; monitor; manage milking hygiene

The Five-Point Mastitis Control Plan

Internationally proven. Every dairy herd should implement all five points — not just one or two.

01

Post-Milking Teat Dipping

Dip all 4 teats in 0.5% iodine post-dip within 30 seconds of unit removal. Kills bacteria before teat canal closes. Non-negotiable — this single step reduces new infection rate by 50%.

02

Dry-Cow Therapy

Infuse all 4 quarters with long-acting IMM antibiotic at dry-off. Add teat sealant for cows in high-risk housing. Eliminates existing subclinical infections and protects through the dry period.

03

Cull Chronic Cases

Cows with 3+ clinical cases per lactation or SCC persistently above 1M are profit destroyers. They infect pen mates. Calculate the cost — culling almost always wins economically.

04

Maintain Milking Equipment

Check vacuum (40–44 kPa) and pulsation (55–65 cycles/min) monthly. Replace liners every 2,500 milkings or 3 months. Faulty equipment is a top 3 cause of mastitis on commercial farms.

05

Treat Clinical Cases Promptly

Identify cases at morning milking by stripping foremilk. Start IMM antibiotic same day. Delayed treatment → chronic infection → quartered cow. Record drug, dose, and withdrawal in HerdManager.co.

Teat Dipping Protocol

The right product, right concentration, right technique. Most farms do it wrong.

Pre-Dip (Before Milking)

0.1% iodine or 0.5% chlorhexidine. Apply, leave 30 seconds minimum, wipe completely dry with individual paper towel per cow. Pre-dip targets environmental mastitis (E. coli, Klebsiella).

Post-Dip (After Milking)

0.5% iodine post-dip. Cover entire teat — top two-thirds minimum. Do NOT wipe off. Apply within 30 seconds of unit removal while teat canal is still open. Critical for contagious mastitis prevention.

Dip Concentration

Iodine teat dips: 0.1% pre-dip, 0.5% post-dip. Do not over-dilute (reduces efficacy). Do not under-dilute (causes teat-end damage and irritation). Use a calibrated dispenser.

Spray vs Dip

Dipping (cup applicator) gives better coverage than spraying. If using a spray, use pressure sprayer at 10–15 cm distance, cover all surfaces. Single dip cups are most hygienic — change after each use.

SCC Monitoring

Somatic Cell Count is your early warning system. Track it monthly — act before clinical signs appear.

SCC Range (cells/mL) Status Milk Loss Action Required
< 100,000 Excellent None Maintain current protocol
100,000 – 200,000 Good Minimal Monitor monthly
200,000 – 400,000 Warning 2–7% CMT test, review hygiene, check milking equipment
400,000 – 1,000,000 Action 7–16% Treat subclinical infection, review DCT compliance
> 1,000,000 Chronic / Cull >16% Consider culling — infection risk to herd

California Mastitis Test (CMT) — Field Use

CMT is the cheapest mastitis diagnostic available. Strip 1–2 mL foremilk from each quarter into the paddle. Add equal volume CMT reagent. Rotate for 10 seconds. No gel = negative. Slight gel = trace. Distinct gel = ++ (subclinical). Strong gel = +++ (clinical/chronic). Use monthly on all cows above 200,000 SCC.

Dry-Cow Therapy

The dry period is your best window to cure existing infections and protect through calving. DCT is the highest-ROI mastitis intervention.

When to Administer

At dry-off (last milking). Infuse all 4 quarters regardless of SCC status (blanket DCT) for high-risk housing. Selective DCT (SCC <200K, no clinical history) is appropriate for well-managed low-risk herds.

Dry-Cow Products

Long-acting dry-cow tubes based on cloxacillin benzathine, cefalonium or cefquinome are widely used, and amoxicillin/cloxacillin combinations are also sold. Each product sets its own rules — usually a minimum time between treatment and calving plus a milk-withholding time after calving — so follow the product label and your vet exactly.

Teat Sealant

Internal teat sealants (bismuth subnitrate paste — e.g., Teatseal, Orbeseal) physically block the teat canal. They contain no antibiotic, so most labels set no milk withdrawal — strip the plug out at the first milkings after calving. Use after DCT infusion, or alone in very low-SCC cows. Highly effective in loose-housed herds.

Milk Withholding After Calving

Milk from DCT-treated cows must be kept out of the tank after calving until the withdrawal time on the product label has passed. Record the infusion date and product in HerdManager.co so the treatment is on the cow's record when she calves.

Treatment of Clinical Mastitis

Act fast. Every 12-hour delay increases the risk of permanent quarter damage.

Drug Route Milk Withdrawal Best For
Cefquinome (IMM) Intramammary Per product label Most clinical mastitis
Cefapirin (IMM) Intramammary Per product label Mild/moderate clinical
Amoxicillin (IMM) Intramammary Per product label Strep/gram-positive
Oxytetracycline (systemic) IM injection Per product label Systemic + IMM combo
Penicillin G (systemic) IM injection Per product label Streptococcal mastitis
NSAIDs (Flunixin/Meloxicam) IV/IM Per product label Pain relief, reduce inflammation — always add for acute cases

Milk withdrawal: always follow the product label

Withdrawal times belong to each product, not just the drug name: two brands of the same antibiotic can carry different milk withdrawal times, and approved products and times differ between countries. Discard milk for the full time on the label of the product you used — or your vet's written instruction for any off-label use — and record the treatment in HerdManager.co so the Milk Withdrawal Active alert runs until the safe date. Our free Withdrawal Clock works out the exact safe time.

Chloramphenicol is banned in food-producing animals

Never use chloramphenicol, nitrofurans, or nitroimidazoles in dairy animals. Their use in food-producing animals is prohibited in the US, UK, Canada and EU, and residues lead to milk rejection and legal penalties. Always consult a licensed veterinarian for treatment protocols.

Track Mastitis with HerdManager.co

Every mastitis case, treatment and withdrawal period — logged and followed up.

Health Event Log

Record every mastitis case as a health event with its severity, symptoms, vet and notes, and add each treatment to the case's treatment log. The full health history stays on the cow's record.

Milk Withdrawal Alerts

Set a withdrawal period on each medicine; when it is given, the app shows a daily Milk Withdrawal Active alert until the safe date.

Mastitis Status with Milk Records

Log a mastitis status — none, subclinical or clinical — with each cow's milk record, so infected cows sit right next to their yield.

Mastitis Alerts

A mastitis-suspicion alert appears on the dashboard when a milk record is marked subclinical or clinical. Schedule herd CMT tests as farm events and get in-app reminders before they are due.

Cull-or-Keep Decisions

Every case and treatment stays on the cow's record, so repeat cases are easy to spot. Our free Cull-or-Keep calculator compares the cost of keeping a cow with replacing her.

Record in the Shed

HerdManager.co works in any phone browser and can be added to your home screen, so cases and treatments are logged at the cow side. It needs an internet connection.

Milking Hygiene & Equipment

Good milking routine is the foundation. Equipment failure is a silent mastitis cause on many farms.

Milking Routine (every milking)

1. Strip 3–4 squirts foremilk (check for abnormalities). 2. Pre-dip — 30-second contact. 3. Wipe dry with individual paper towel. 4. Attach unit. 5. Milk out fully. 6. Post-dip immediately on removal.

Equipment Maintenance

Check vacuum gauge monthly (40–44 kPa). Check pulsation (55–65 cycles/min). Replace rubber liners every 2,500 milkings or 3 months. Backflush clusters between cows. Sanitize milking line daily with caustic then acid wash.

Housing Cleanliness

Scrape manure twice daily minimum. Keep lying area dry (wet bedding = massive environmental mastitis pressure). Lime alleys and lying areas weekly. Adequate space per cow (5–6 m² loose housing).

Staff Training

Milking staff must follow routine consistently — every milking, every cow. Train new staff before they touch animals. A single untrained relief milker can spike farm SCC in 2 weeks.

Fresh Cow Management

Check all fresh cows (0–14 DIM) at every milking. Strip foremilk, check udder temperature and firmness. Transition stress = high mastitis susceptibility. CMT all fresh cows at Day 3 and Day 10.

Water Quality

Contaminated water in the milking machine wash cycle transfers bacteria to teat surfaces. Test water source annually for coliform counts. Use chlorinated water for equipment washing.

Frequently Asked Questions

Common mastitis questions from dairy farmers.

What is the first-line treatment for clinical mastitis?
Intramammary cefquinome or cefapirin are common first-line treatments for clinical mastitis where they are licensed, but approved products differ by country and the right drug depends on the pathogen. Ask your vet, ideally after a milk culture. Record every treatment in HerdManager.co with the medicine's withdrawal period, and the app shows a daily Milk Withdrawal Active alert until the milk is safe.
How do I do a CMT test?
Strip 1–2 mL foremilk from each quarter into CMT paddle. Add equal volume CMT reagent. Rotate gently for 10 seconds. No gel = clear. Slight gel = trace/+. Distinct gel = ++. Strong gel = +++ (mastitis). CMT kits are sold by veterinary and farm-supply stores.
What is a normal SCC for dairy cows?
Below 200,000 cells/mL is your target. Below 100,000 is excellent. Above 400,000 requires immediate action. Above 1,000,000 indicates chronic infection — culling should be considered.
Is mastitis different in buffaloes?
Yes. Buffalo milk's higher fat content makes CMT less reliable. Subclinical mastitis is often underdiagnosed in buffalo herds. Monthly SCC lab testing is essential. Post-milking teat dipping is extra critical due to longer teat exposure during oxytocin-dependent let-down.
What is dry-cow therapy and why is it important?
DCT is infusing quarters with a long-acting antibiotic at dry-off to cure existing subclinical infections and protect through the dry period. It is the single highest-ROI mastitis intervention — the tubes cost little compared with the milk lost to a new infection in the next lactation. Many herds now treat only infected cows and seal the rest (selective DCT).
How long is antibiotic withdrawal for mastitis drugs?
Withdrawal times belong to each product, not just the drug: two brands of the same antibiotic can carry different milk withdrawal times, and they differ between countries. Use the milk withdrawal time on the label of the exact product you used — dry-cow tubes usually state a minimum time between treatment and calving plus a withholding time after calving — or your vet's written instruction for any off-label use. Record each treatment in HerdManager.co with its withdrawal period so the app shows a daily Milk Withdrawal Active alert until the safe date.
How much does mastitis cost per cow per year?
Mastitis is usually the costliest disease in a dairy herd, and most of the loss is hidden: reduced yield from subclinical cases, plus discarded milk, drugs, vet time, labour and early culling for clinical cases. Prevention through the five-point plan costs a fraction of treating cases.
What causes a sudden spike in farm SCC?
Common causes: new infected animal introduced without quarantine, untrained relief milker, milking machine fault (check vacuum/pulsation), bedding became very wet (a long wet spell), change in milking order. Investigate within 24 hours of noticing SCC spike.
Should I use blanket or selective dry-cow therapy?
Selective DCT — antibiotic tubes only for cows with a high SCC or a recent clinical case, and an internal teat sealant for the rest — is now standard practice in many US, UK and Canadian herds and is encouraged by antimicrobial-stewardship guidance. It needs reliable individual SCC and case records. Blanket DCT (all cows, all quarters) may still be advised by your vet where infection pressure is high.
How do I prevent mastitis in wet weather?
Long wet spells are high-risk: wet bedding, mud and humidity raise environmental mastitis. Change or top up bedding more often, lime alleys twice weekly, keep cows out of muddy areas, and step up teat-cleanliness checks at milking.
Can mastitis spread between cows?
Contagious mastitis (Staphylococcus aureus, Streptococcus agalactiae) spreads via milking equipment and milker hands. Milk infected cows last. Use separate cluster or backflush. Glove up. Environmental mastitis (E. coli, Klebsiella) does not spread cow-to-cow — it comes from housing.
Which teat dip should I use?
Iodine-based post-dip (0.5%) is the most widely used standard and is sold under many brands. Chlorhexidine 0.5% is a good alternative for iodine-sensitive teat skin. Pre-dip: 0.1% iodine or 0.5% chlorhexidine. Use a product approved for teat use in your country and follow its label.
When should I cull a mastitis cow?
Cull if: 3+ clinical cases in current lactation; SCC persistently above 1M for 3+ months; quarter has no milk production (fibrosis); animal requires banned drug not suitable for food-producing animals. Calculate: cull value + replacement heifer cost vs continued treatment cost.
Does heat stress increase mastitis risk?
Yes. Heat stress suppresses immune function, increasing susceptibility to environmental mastitis. SCC typically rises in the hottest summer months. Increase cooling, water access, and milking hygiene checks in summer. Monitor fresh cows closely in hot months.
How does HerdManager.co help with mastitis management?
HerdManager.co lets you log a mastitis status (none, subclinical or clinical) with each cow's milk record and raises a mastitis-suspicion alert when a cow is marked subclinical or clinical. You can schedule CMT tests as farm events, record each case as a health event with its treatment log, and set the withdrawal period on each medicine so the app shows a daily Milk Withdrawal Active alert until the milk is safe. Each cow's case history stays on her record to support treat-or-cull decisions.
What is a teat sealant and does it work?
Bismuth subnitrate paste (Teatseal, Orbeseal) physically blocks the teat canal during the dry period. It contains no antibiotic, so most labels set no milk withdrawal. Randomised trials show 40–60% reduction in new intramammary infections during the dry period. Widely used alongside selective dry-cow therapy.
How often should I replace milking machine liners?
Every 2,500 milkings or 3 months — whichever comes first. Cracked, swollen, or discoloured liners harbour bacteria and cause teat-end damage. Liner replacement is one of the cheapest mastitis prevention investments.
What is the difference between contagious and environmental mastitis?
Contagious mastitis (Staph aureus, Strep agalactiae) spreads cow-to-cow via milking. Control: milk infected cows last, cull chronics, backflush clusters. Environmental mastitis (E. coli, Klebsiella, Strep uberis) comes from bedding and manure. Control: housing hygiene and DCT.
How do I test water quality for the milking machine?
Take water samples from the source and from post-wash rinse water. Test for total coliform count (target <1 CFU/mL) and total bacterial count. Water-testing and veterinary diagnostic laboratories run these tests at modest cost. Test annually or after any housing/water infrastructure change.
Is there a vaccination against mastitis?
Partly. Core-antigen E. coli (J5-type) vaccines are widely used in US and Canadian herds to reduce the severity of coliform mastitis, and a combined E. coli / Staph aureus vaccine is licensed in the UK and EU. They reduce severity and losses rather than prevent infection, so the five-point plan remains the foundation — ask your vet whether vaccination suits your herd.

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